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KMID : 1039120200090020174
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Clinical and Experimental Vaccine Research
2020 Volume.9 No. 2 p.174 ~ p.178
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Potential use of 3-(trimethoxysilyl)propyldimethyl octadecyl ammonium chloride as an antimicrobial and antiviral agent for the disinfection of personal protective equipment
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Kim Yu-Jin
Youn Ha-Na
Kim Jun-Beom
Lee Da-Ye
Go Seong-Hye
Park Ji-Eun
Lee Sun-Hak
Noh Jin-Yong
Nahm Sang-Soep
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Abstract
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Currently, no vaccine or established therapeutic agents are available for coronavirus disease 2019. The sharp increase in demand for personal protective equipment (PPE) necessitates an improvement in the protective efficacy of PPE. We evaluated the potential antimicrobial and antiviral effects of a surface-coating disinfectant (3-(trimethoxysilyl)propyldimethyl octadecyl ammonium chloride, Si-QAC) when applied onto PPE. Si-QAC-pre-coated PPE was artificially contaminated with either influenza virus or Salmonella. The results showed significantly reduced influenza and Salmonella titers in Si-QAC-coated PPE; these antimicrobial effects lasted 7 days. This suggests that this surface-coating disinfectant effectively reduces pathogen contamination of PPE, enabling their safe and long-term use.
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KEYWORD
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Coating disinfectant, Si-QAC, Antimicrobial, Antiviral, Long-lasting
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